Catalogue Number:A771278
Chemical Name:Arimoclomol
Synonyms:(R)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide
CAS Number:289893-25-0
Molecular Formula:C₁₄H₂₀ClN₃O₃
Appearance:White to Off-White Solid
Melting Point:93 – 95o C
Molecular Weight:313.78
Storage:-20°C, Hygroscopic
Solubility:Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.
References:Kieran, Dairin., et al.: Nature Medicine., 10, 402 (2004); Brown, Ian R., et al.: Ann N Y Acad Sci., 1113, 147 (2007); Traynor, B. J., et al.: Neurology., 67, 20 (2006),
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Posted inMaterials
CAS:289893-25-0|Arimoclomol
