CAS:31690-11-6|Arfolitixorin

Catalogue Number:A767530
Chemical Name:Arfolitixorin
Synonyms:N-[4-[(6aR)-3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl]-L-glutamic acid; (6R)-5,10-Methylene-5,6,7,8-tetrahydrofolic acid; (6R)-5,10-Methylenetetrahydrofolate; 5,10-Methylene-(6R)-tetrahydrofolic acid; L-(+)-Methylenetetrahydrofolic acid; d-N5,N10-Methylene-L-tetrahydrofolic acid;
CAS Number:31690-11-6
Molecular Formula:C20H23N7O6
Molecular Weight:457.44
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Arfolitixorin is a folate prodrug that is used in the treatment for colorectal cancer as a way for increase in efficacy and reducing the side effects of antimetabolites used in cancer treatment.
References:Wettergren, Y., et al.: Cancer Chemother. Pharmacol., 75, 37-47 (2015); Gustavsson, B., et al.: Invest New Drugs., 33, 1078-85 (2015);
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