CAS:3308-94-9|2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane

Catalogue Number:C380430
Chemical Name:2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane
Synonyms:1,1-(Ethylenedioxy)-4-chloro-1-(4-fluorophenyl)butane; 1-(4-Fluorophenyl)-4-chlorobutan-1-one Ethylene Ketal; 1-Chloro-4,4-(ethylenedioxy)-4-(4-fluorophenyl)butane; 2-(3-Chloropropyl)-2-(4-fluorophenyl)dioxolane; 2-(3-Chloropropyl)-2-(4′-fluorophenyl)-1,3-dioxolane; 2-(3-Chloropropyl)-2-(p-fluorophenyl)-1,3-dioxolane; 2-(3-Chloropropyl)-2-(p-fluorophenyl)dioxolane; 2-(4-Fluorophenyl)-2-(3-chloropropyl)-1,3-dioxolane; 3-Chloropropyl 4-Fluorophenyl Ketone Ethylene Ketal; 3-p-Fluorobenzoylpropyl Chloride Ethylene Ketal; 4,4-(Ethylenedioxy)-4-(4-fluorophenyl)butyl Chloride; 4-(4-Fluorophenyl)-4,4-ethylenedioxy-1-chlorobutane; 4-(p-Fluorophenyl)-4,4-ethylenedioxy-1-chlorobutane; 4-Chloro-1,1-ethylenedioxy-1-(4-fluorophenyl)butane; 4-Chloro-1-(p-fluorophenyl)-1-butanone Cyclic Ethylene Acetal; 4
CAS Number:3308-94-9
Molecular Formula:C₁₂H₁₄ClFO₂
Appearance:Colourless to Pale Yellow Oil
Molecular Weight:244.69
Storage:4°C
Solubility:Chloroform (Sparingly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Boiling Point
317.2°C @ 760 Torr (SciFinder)
Applications:2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane is used as a reagent to synthesize Piperidine (P479985) receptor ligands, compounds that have potential antipsychotic activity. 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane is also used as a reagent to synthesize Bromoperidol, a neuroleptic drug that is closely related to Haloperidol (H103700).
References:Gilligan, P., et al.: J. Med. Chem., 35, 4344 (1992); McCarrick, M. & Kollman, P.: J. Comp. Mol. Des., 13, 109 (1999); Niemegeers, C. & Janssen, P.: Arz.-Fors., 24, 45 (1974)
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