CAS:34031-32-8|Auranofin

Catalogue Number:A794750
Chemical Name:Auranofin
Synonyms:[1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold;
CAS Number:34031-32-8
Molecular Formula:C₂₀H₃₄AuO₉PS
Appearance:White to Off-White Solid
Melting Point:104-110°C
Molecular Weight:678.48
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Carbohydrates and Oligosaccharides;
Applications:Auranofin is a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Kizu, R., et al.: Chem. Pharm. Bull., 41, 1261 (1993), Itokazu, M., et al.: Clin. Ther., 17, 60 (1995), Kean, W.F., et al.: Br. J. Rheumatol., 36, 560 (1997),
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