CAS:34157-83-0|Celastrol

CAS:34157-83-0|Celastrol

Catalogue Number:C249500
Chemical Name:Celastrol
Synonyms:3-Hydroxy-2-oxo-24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid; Tripterin; Tripterine
CAS Number:34157-83-0
Molecular Formula:C₂₉H₃₈O₄
Appearance:Orange to Red Solid
Melting Point:187-189°C
Molecular Weight:450.61
Storage:-20°C
Solubility:Chloroform (Slightly), Hexanes (Slightly, Heated), Methanol
Category:Standards; Steroids; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. Celastrol is also a leptin sensitizer with the potential to reduce weight in obesity (see W499200).
References:Senger, D., et al.: Science, 219, 983 (1983),
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