CAS:35364-15-9|1-(2-Amino-5-hydroxyphenyl)propan-1-one

Catalogue Number:A611480
Chemical Name:1-(2-Amino-5-hydroxyphenyl)propan-1-one
Synonyms:2′-Amino-5′-hydroxypropiophenone; AHPP
CAS Number:35364-15-9
Molecular Formula:C₉H₁₁NO₂
Appearance:Light Yellow to Brown Solid
Melting Point:>138°C (dec.)
Molecular Weight:165.19
Storage:-20°C, Hygroscopic
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Miscellaneous;
Applications:1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-​ring-​modified (RS)​-​camptothecin analogs as antitumor agents.
References:Henegar, K., et al.: J. Org. Chem., 62, 6588 (1997); Ejima, A., et al.: Chem. Pharma. Bull., 40, 683 (1992)
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