CAS:3715-64-8|3`-Deoxy-5`-thymidylic Acid

Catalogue Number:D281778
Chemical Name:3`-Deoxy-5`-thymidylic Acid
Synonyms:3′-Deoxy-thymidine, 5′-(Dihydrogen phosphate) (8CI); 3′-Deoxy-thymidine, 5′-Phosphate (7CI)
CAS Number:3715-64-8
Molecular Formula:C₁₀H₁₅N₂O₇P
Molecular Weight:306.21
Category:Standards;
Applications:3`-Deoxy-5`-thymidylic Acid has been shown to complex with human thymidylate kinase via hydrogen bonding between Arg97 residues and phosphate groups. This interaction leads to the closed P-loop conformation in human thymidylate kinase, which promotes phosphorylation of nucleotides and has the potential as a model for novel compounds as a result of structure-based design studies.
References:Ostermann, N.; et al.: Biochemistry, 42, 2568 (2003)
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