CAS:4022-81-5|1-(4-Chlorophenyl)biguanide Hydrochloride

Catalogue Number:C378540
Chemical Name:1-(4-Chlorophenyl)biguanide Hydrochloride
Synonyms:N-(4-Chlorophenyl)imidodicarbonimidic Diamide Hydrochloride; 1-(p-Chlorophenyl)biguanide Monohydrochloride; I N-(4-Chlorophenyl)midodicarbonimidic Diamide Monohydrochloride; 1-(p-Chlorophenyl)biguanide Monohydrochloride; N-(4-Chlorophenyl)imidodicarbonimidic Diamide Monohydrochloride; N-p-Chlorophenylbiguanide Hydrochloride;
CAS Number:4022-81-5
Alternate CAS #
5304-59-6-unlabelled
Molecular Formula:C₈H₁₀ClN₅ • HCl
Appearance:White to Off-White Solid
Melting Point:227-230°C
Molecular Weight:211.65 + 36.46
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit significantly dihydrofolate reductase (DHFR).
References:Baccanari, D., et al.: Biochemistry, 21, 5068 (1982), Ahrweiler, P., et al.: J. Bacteriol., 170, 3301 (1988), Zolli-Juran, M., et al.: Bioorg. Med. Chem. Lett., 13, 2493 (2003),
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