CAS:426226-35-9|(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride

Catalogue Number:A596515
Chemical Name:(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride
Synonyms:Methyl (1R,4S)-4-Aminocyclopent-2-ene-1-carboxylate Hydrochloride
CAS Number:426226-35-9
Alternate CAS #
352226-74-5
Molecular Formula:C₇H₁₁NO₂ • HCl
Molecular Weight:141.17 + 36.46
Category:Building Blocks; Miscellaneous;
Applications:(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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