CAS:487021-52-3|AR-AO 14418

Catalogue Number:A765500
Chemical Name:AR-AO 14418
Synonyms:N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea; AR 0133418; GSK 3B Inhibitor VIII;
CAS Number:487021-52-3
Molecular Formula:C₁₂H₁₂N₄O₄S
Appearance:Pale Yellow to Light Yellow Solid
Melting Point:208-210?C (dec.)
Molecular Weight:308.31
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AR-AO 14418 is a glycogen synthase kinase 3? (GSK-3?) inhibitor (1,2,3). GSK-3? is a serine/threonine protein kinase that is involved numerous diseases such as type II diabetes and Alzheimer’s.
References:(1) Koh, S., et al.:Toxicol., 247, 112 (2008)
(2) Vadivelan, S., et al.: Eur. J. Med. Chem., 44, 2361 (2009)
(3) Min, W., et al.: Neuropharmacol., 56, 463 (2009)
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