CAS:496864-15-4|Aloisine RP106

Catalogue Number:A575475
Chemical Name:Aloisine RP106
Synonyms:RP106, 7-n-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine;
CAS Number:496864-15-4
Molecular Formula:C₁₇H₁₉N₃O
Appearance:Off-White to Pale Yellow Solid
Melting Point:182-184°C
Molecular Weight:281.35
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk1/cyclin B, Cdk5/p35, and GSK-3 ( IC50 =700nM 1.5 uM, and 920 nM, respectively).
References:Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003)
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