CAS:51687-55-9|De-diazepin-2-one Clotiazepam

Catalogue Number:C416770
Chemical Name:De-diazepin-2-one Clotiazepam
Synonyms:(2-Chlorophenyl)[5-ethyl-2-(methylamino)-3-thienyl]methanone
CAS Number:51687-55-9
Molecular Formula:C₁₄H₁₄ClNOS
Molecular Weight:279.78
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:De-diazepin-2-one Clotiazepam is an impurity of Clotiazepam (C587410) which is a thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.
References:Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);
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