CAS:59457-26-0|1-Chloro-1,2-benziodoxol-3(1H)-one

Catalogue Number:C363558
Chemical Name:1-Chloro-1,2-benziodoxol-3(1H)-one
Synonyms:1-Chloro-1,2-benziodoxol-3-one; 1-Chlorobenziodoxol-3-one;
CAS Number:59457-26-0
Molecular Formula:C₇H₄ClIO₂
Appearance:White to Light Yellow Solid
Melting Point:170- 173° C
Molecular Weight:282.46
Storage:-20°C
Solubility:Chloroform (Sparingly), DMSO (Slightly)
Stability
Moisture Sensitive
Category:Building Blocks; Miscellaneous;
Applications:1-Chloro-1,2-benziodoxol-3(1H)-one is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References:Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),
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