CAS:62004-05-1|2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide

Catalogue Number:C358215
Chemical Name:2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide
CAS Number:62004-05-1
Molecular Formula:C₁₂H₉F₃N₂O₂
Molecular Weight:270.21
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide is a derivative of Leflunomide(L322750) which is an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.
References:Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009); Uckun, Fatih M. et al., PCT Int. Appl. 41 pp. (2002);
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