CAS:654653-93-7|(aR,bS)-rel-Bedaquiline

Catalogue Number:B119555
Chemical Name:(aR,bS)-rel-Bedaquiline
Synonyms:(αR,βS)-rel-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
CAS Number:654653-93-7
Molecular Formula:C₃₂H₃₁BrN₂O₂
Appearance:Off-White to Pale Yellow Solid
Melting Point:>180°C (dec.)
Molecular Weight:555.5
Storage:-20°C
Solubility:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(aR,bS)-rel-Bedaquiline is a promising diarylquinoline candidate in clinical development for the treatment of tuberculosis. (aR,bS)-rel-Bedaquiline inhibits mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis.
References:Guillemont, J. et al.: Fut. Med. Chem., 3, 1345 (2011); Koul, A. et al.: Nat. Chem. Biol., 3, 323 (2007)
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