CAS:6640-24-0|1-(3-Chlorophenyl)piperazine

Catalogue Number:C379590
Chemical Name:1-(3-Chlorophenyl)piperazine
Synonyms:1-(m-Chlorophenyl)piperazine; 4-(3-Chlorophenyl)piperazine; N-(3-Chlorophenyl)piperazine; N-(m-Chlorophenyl)piperazine; NSC 49307; mCPP;
CAS Number:6640-24-0
Alternate CAS #
13078-15-4 HCl salt
Molecular Formula:C₁₀H₁₃ClN₂
Appearance:Colourless to Orange Oil
Molecular Weight:196.68
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Sparingly)
Category:Standards; Stimulant; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
References:(1) Bo Wen, et al.: Drug Metab. Dispos., 36, 841 (2008)
(2) Maes, M., et al.: J. Clin. Psychopharmacol., 17, 358 (1997)
(3) Fiorella, D., et al.: Psychopharmacology, 119, 220 (1995)
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