CAS:67914-60-7|1-Acetyl-4-(4-hydroxyphenyl)piperazine

Catalogue Number:A179045
Chemical Name:1-Acetyl-4-(4-hydroxyphenyl)piperazine
Synonyms:1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone; 4-(4-Acetylpiperazino)phenol; 1-Acetyl-4-(p-hydroxyphenyl)piperazine; Ketoconazole Intermediate (branched chain of ketoconazole)
CAS Number:67914-60-7
Molecular Formula:C₁₂H₁₆N₂O₂
Appearance:White to Off-White Solid
Melting Point:180-182ºC
Molecular Weight:220.27
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-Acetyl-4-(4-hydroxyphenyl)piperazine is an intermediate used to prepare Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo.
References:Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)
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