CAS:6966-01-4|2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester

Catalogue Number:A601863
Chemical Name:2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester
Synonyms:3-Amino-6-bromo-2-pyrazinecarboxylic acid Methyl Ester; Methyl 3-Amino-6-bromopyrazine-2-carboxylate; NSC 18700;
CAS Number:6966-01-4
Molecular Formula:C₆H₆BrN₃O₂
Appearance:Orange Solid
Melting Point:164-166˚C
Molecular Weight:232.03
Storage:4°C, Inert atmosphere
Solubility:Chloroform, Ethyl Acetate, Methanol
Category:Building Blocks; Miscellaneous;
Applications:2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
References:Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)
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