CAS:697299-82-4|N-De[2-(methylsulfonyl)ethyl] Lapatinib

Catalogue Number:D231270
Chemical Name:N-De[2-(methylsulfonyl)ethyl] Lapatinib
Synonyms:6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine; [6-(5-Aminomethylfuran-2-yl)quinazolin-4-yl][3-chloro-
CAS Number:697299-82-4
Molecular Formula:C₂₆H₂₀ClFN₄O₂
Appearance:Pale Yellow to Light Beige Solid
Melting Point:>141ºC (dec.)
Molecular Weight:474.91
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.
References:He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),
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