CAS:75166-64-2|3-Aminononan-2-ol

Catalogue Number:A751660
Chemical Name:3-Aminononan-2-ol
Synonyms:3-Amino-2-nonanol
CAS Number:75166-64-2
Molecular Formula:C₉H₂₁NO
Molecular Weight:159.27
Category:Building Blocks; Miscellaneous;
Applications:3-Aminononan-2-ol is an intermediate in the synthesis of rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt (H825550), which is a potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does not inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Potent PDE-2 inhibitor.
References:Lorbar, M., et al.: J. Mol. Cell. Cardiol., 31, 401 (1999), Verde, I., et al.: Br. J. Pharmacol., 127, 65 (1999),
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