CAS:76824-16-3|3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide

Catalogue Number:A611525
Chemical Name:3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide
Synonyms:USP Famotidine Related Compound D; Famotidine EP Impurity D
Impurity:Famotidine EP Impurity D
CAS Number:76824-16-3
Molecular Formula:C₈H₁₃N₅OS₂
Appearance:White to Pale Yellow Solid
Melting Point:>140°C (dec.)
Molecular Weight:259.35
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Heated, Soni
Stability
Hygroscopic
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide is an impurity in the synthesis of Famotidine (F102250) histamine H2-receptor antagonist. Antiulcerative.
References:Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982), Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984), Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985),
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