CAS:77521-29-0|(R,S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

Catalogue Number:A611500
Chemical Name:(R,S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Synonyms:D,L-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid; AMPA;
CAS Number:77521-29-0
Alternate CAS #
74341-63-2 – deleted CAS Number:Molecular Formula:C₇H₁₀N₂O₄
Appearance:White to Off-White Solid
Melting Point:>162°C (dec.)
Molecular Weight:186.17
Storage:-20°C
Solubility:Water
Stability
Hygroscopic
Category:Research Tools; Molecular Biology; Neurochemicals;
Applications:A potent and selective agonist of the putative, excitatory neurotransmitter L-glutamic acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists.
References:Krogsgaard-Larsen, et al.: Nature, 284, 64 (1980), Honore, T., et al.: J. Neurochem., 38, 173 (1982), MacDonald, J.F., et al.: Science, 253, 1132 (1991)
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