CAS:789-61-7|2′-Deoxy-6-thio Guanosine

Catalogue Number:D281650
Chemical Name:2′-Deoxy-6-thio Guanosine
Synonyms:2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione; 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine; 2′-Deoxythioguanosine; 2′-Desoxy-6-thioguanosine; NSC 71261; TGdR; Thioguanine Deoxyriboside; β-Thioguanine Deoxyriboside;
CAS Number:789-61-7
Molecular Formula:C₁₀H₁₃N₅O₃S
Appearance:Yellow to Brown Solid
Melting Point:>172°C (dec.)
Molecular Weight:283.31
Storage:-20°C
Solubility:DMF (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
Stability
Hygroscopic
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References:Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999);
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