CAS:848133-88-0|(2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide

Catalogue Number:C365008
Chemical Name:(2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide
Synonyms:((E)-4-(Dimethylamino)but-2-enoyl Chloride Compound With (E)-N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS Number:848133-88-0
Molecular Formula:C₁₈H₁₉ClN₄O₂
Molecular Weight:358.82
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide was used in the study for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
References:Tsou, H., et al.: J. Med. Chem., 48, 1107 (2005);
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