CAS:848139-78-6|6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

Catalogue Number:A604050
Chemical Name:6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Synonyms:4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinoline; 6-Amino-4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxyquinoline
CAS Number:848139-78-6
Molecular Formula:C₂₄H₂₀ClN₅O₂
Appearance:Off-White to Pale Yellow Solid
Melting Point:236-238ºC (dec.)
Molecular Weight:445.9
Storage:4°C
Solubility:Dichloromethane (Slightly), DMSO (Slightly)
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.
References:Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)
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