CAS:85175-65-1|3-(3-Chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one

Catalogue Number:C375260
Chemical Name:3-(3-Chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one
Synonyms:3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one;
CAS Number:85175-65-1
Molecular Formula:C₁₅H₂₀ClNO₃
Molecular Weight:297.78
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-(3-Chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one is an impurity in the synthesis of Ivabradine (I940500), a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.
References:Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),
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