CAS:852808-01-6|N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine

Catalogue Number:C852800
Chemical Name:N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine
CAS Number:852808-01-6
Molecular Formula:C₁₅H₁₄ClN₅
Appearance:Off-White Solid
Molecular Weight:299.76
Solubility:DMSO
Category:Building Blocks; Miscellaneous;
Applications:N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
References:Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)
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