CAS:873697-71-3|CK 1827452

Catalogue Number:C544000
Chemical Name:CK 1827452
Synonyms:Methyl 4-[[2-Fluoro-3-[N’-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate; 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester; Omecamtiv Mecarbil
CAS Number:873697-71-3
Molecular Formula:C₂₀H₂₄FN₅O₃
Appearance:White to Off-White Solid
Melting Point:187-190ºC
Molecular Weight:401.43
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
References:Meijs, M. et al.: Eur. J. Heart. Fail., 14, 232 (2012); Malik, F. et al.: J. Mol. Cell. Card., 51, 454 (2011)
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