CAS:88899-55-2|Bafilomycin A1

Catalogue Number:B110000
Chemical Name:Bafilomycin A1
Synonyms:21-O-De(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Oxacyclohexadecane, hygrolidin deriv.; (-)-Bafilomycin A1; NSC 381866; [7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-8-Hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
CAS Number:88899-55-2
Molecular Formula:C₃₅H₅₈O₉
Appearance:White to Off-White Solid
Melting Point:>106°C (dec.)
Molecular Weight:622.83
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Research Tools; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Bafilomycin A1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
References:Bownman, E., et al.: PNAS, 85, 7972 (1988); Umata, T., et al.: J. Biol. Chem., 265, 21940 (1990); Saurin, A., et al.: Biochem.
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