CAS:928201-45-0|Trelagliptin Trifluoroacetic Acid Salt

Catalogue Number:A627960
Chemical Name:Trelagliptin Trifluoroacetic Acid Salt
Synonyms:2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile Trifluoroacetic Acid Salt
CAS Number:928201-45-0
Molecular Formula:C₂₀H₂₁F₄N₅O₄
Molecular Weight:471.41
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile trifluoroacetic acid salt is a potent, selective, and noncovalent inhibitor of dipeptidyl peptidase IV (DPP-4). This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.
References:Augeri, D., et al.: J. Med. Chem., 48, 5025 (2005), Drucker, D., et al.: Lancet, 368, 1696 (2006), Cvetkovic, R., et al.: Drugs, 67, 935 (2007),
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