CAS:95633-27-5|7-Azido-4-methylcoumarin

Catalogue Number:A884803
Chemical Name:7-Azido-4-methylcoumarin
Synonyms:7-Azido-4-methyl-2H-1-benzopyran-2-one4-Methyl-7-azidocoumarin
CAS Number:95633-27-5
Molecular Formula:C₁₀H₇N₃O₂
Molecular Weight:201.18
Category:Research Tools;
Applications:7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5′-phosphate (PLP)-dependent enzymes (e.g. cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine β-synthase (CBS) inhibitors and activators. The aromatic azide moiety is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with ?ex = 365 nm and ?em = 450 nm. It has been characterized as a novel fluorescent photoactive probe for use in photoaffinity labeling of the substrate binding site of human phenol sulfotransferase (SULT1A1 or P-PST-1)
References:Chen G, et al. Protein Sci. 1999 Oct;8(10):2151-7.
Collom SL el al. Arch Biochem Biophys. 2007 Mar 1;459(1):59-69
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