CHIR-99021-d4

Chemical Name:CHIR-99021-d4
Alternate CAS #:Unlabelled: 252917-06-9
Molecular Formula:C₂₂H₁₄D₄Cl₂N₈
Molecular Weight:469.36
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:CHIR-99021-d4 is the deuterized or labeled form of CHIR-99021 Hydrochloride (C292150), which is a potent and highly selective inhibitor of glycogen synthase kinases 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
References:Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);
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