Dabrafenib-Glu

Chemical Name:Dabrafenib-Glu
Synonyms:(2S,3S,4S,5R,6R)-6-(2-(5-(2-Aminopyrimidin-4-yl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-2-yl)-2-methylpropoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Molecular Formula:C₂₉H₂₈F₃N₅O₉S₂
Molecular Weight:711.7
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A related compound of Dabrafenib (D101000), an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.
References:Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013);
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