Dehydroxy Tetrapivaloyl Canagliflozin

Chemical Name:Dehydroxy Tetrapivaloyl Canagliflozin
Synonyms:(2S,3R,4S,5R,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxy-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
Molecular Formula:C₄₄H₅₇FO₁₀S
Molecular Weight:796.99
Category:Building Blocks; Miscellaneous;
Applications:Dehydroxy Tetrapivaloyl Canagliflozin is an intermediate in the synthesis of Canagliflozin Dimer (C175225), a dimer impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
References:Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011)
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