Des-(1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide) 4,5-Dehydro 3-Morpholino Apixaban

Chemical Name:Des-(1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide) 4,5-Dehydro 3-Morpholino Apixaban
Synonyms:3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)pyridin-2(1H)-one
Molecular Formula:C₂₀H₂₃N₃O₃
Molecular Weight:353.41
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Des-(1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide) 4,5-Dehydro 3-Morpholino Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
References:Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)
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