(E)-3S,5R-Bis[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-methyl-cyclo[4.1.0]hept-2-ylidene-ethanol

Chemical Name:(E)-3S,5R-Bis[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-methyl-cyclo[4.1.0]hept-2-ylidene-ethanol
Molecular Formula:C₂₁H₄₄O₃Si₂
Molecular Weight:400.74
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(E)-3S,5R-Bis[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-methyl-cyclo[4.1.0]hept-2-ylidene-ethanol is an intermediate used in the synthesis of Calcitriol-d6 (C144502), which is the biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic.
References:Myrtle, J.F., et al.: J. Biol. Chem., 245, 1190 (1970), Lawson, D.E.M., et al.: Nature, 230, 228 (1971), Norman, A.W., et al.: Science, 173, 51 (1971), Suda, T., et al.: Vitamins, 45, 175 (1972), Muindi, J.R., et al.: Clin. Pharmacol. Ther., 72, 648 (2002)
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