Fosaprepitant N-oxide

Chemical Name:Fosaprepitant N-oxide
Molecular Formula:C₂₃H₂₂F₇N₄O₇P
Molecular Weight:630.41
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Fosaprepitant N-oxide is an impurity of Fosaprepitant (F727300), a selective neurokinin-1 (NK-1) receptor antagonist, an antiemetic drug and a prodrug of Aprepitant (A729800).
References:Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000);Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001);Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007);Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009)
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