KO 143

Chemical Name:KO 143
Synonyms:(3S,6S,12aS)-,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4-b]indole-3-propanoic Acid 1,1-Dimethylethyl Ester;
CAS Number:461054-93-3
Molecular Formula:C₂₆H₃₅N₃O₅
Molecular Weight:469.57
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A potent BCRP (breast cancer resistance protein) inhibitor.
References:Allen, J., et al.: Cancer Res., 59, 4237 (1999), van Loevezijn, A., et al.: Bioorg. Med. Chem. Lett., 11, 29 (2001), Raaijmakers, M., et al.: Clin. Cancer Res., 11, 2436 (2005)
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