MZ 1

Chemical Name:MZ 1
Synonyms:(4R)-N-[14-[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide
CAS Number:1797406-69-9
Molecular Formula:C₄₉H₆₀ClN₉O₈S₂
Molecular Weight:1002.64
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:MZ 1, is a BRD4 protein degrader based on PROTAC technology. The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.
References:Gadd, M/ S. et al.: Nat Chem Biol. 2017 May;13(5):514-521;
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