N-Ethyl-4-fluoroaniline Hydrochloride

Chemical Name:N-Ethyl-4-fluoroaniline Hydrochloride
Synonyms:N-Ethyl-p-fluoroaniline Hydrochloride; N-Ethyl-4-fluorobenzenamine Hydrochloride
CAS Number:459-21-2
Alternate CAS #:405-67-4
Molecular Formula:C₈H₁₀FN • HCl
Molecular Weight:139.17
Category:Building Blocks; Miscellaneous;
Applications:N-Ethyl-4-fluoroaniline Hydrochloride can be useful in the study of molecular rearrangement of oximes on reduction with lithium aluminum hydride. It is a salt analog of N-Ethyl-4-fluoroaniline (CAS# 405-67-4), which can be useful in the discovery of positive allosteric modulators of GluN2A-containing NMDARs and synthesis of antimalarial isoneocryptolepine analogs.
References:Lyle, R. E., et al.: J. Org. Chem., 20, 1757 (1955); Hackos, D. H., et al.: Neuron, 89, 983 (2016); Volgraf, M., et al.: J. Med. Chem., 59, 2760 (2016); Szabo, T., et al.: J. Org. Chem., 86, 128 (2021)
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