N-Hydroxysuccinimide-d4

Chemical Name:N-Hydroxysuccinimide-d4
Synonyms:1-Hydroxy-2,5-pyrrolidinedione-d4; N-Hydroxy-2,5-dioxopyrrolidine-d4; 1-Hydroxysuccinimide-d4;
Alternate CAS #:Unlabeled: 6066-82-6
Molecular Formula:C₄HD₄NO₃
Molecular Weight:119.11
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:N-Hydroxysuccinimide-d4 is derived from Succinic Anhydride-d4 (S688773), which is used in the synthesis of propanoyloxy derivatives used as drug absorption modifiers. In addition it is a reagent for novel non-carboxylate inhibitors of AKR1C3. Also, it is the deuterated form of N-Hydroxysuccinimide (H953585), which is an additive used in the carbodiimide method for improved amidations and peptide couplings.
References:Coufalova, L. et al.: Steroids, 78, 435 (2013); Heinrich, D. et al.: Eur. J. Med. Chem., 62, 738 (2013);
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