O-Methyl ent-Dolutegravir

Chemical Name:O-Methyl ent-Dolutegravir
Synonyms:(4S,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Alternate CAS #:4R,12S: 1335210-35-9
Molecular Formula:C₂₁H₂₁F₂N₃O₅
Molecular Weight:433.41
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:O-Methyl ent-Dolutegravir is an impurity of Dolutegravir (D528800), is a second generation Integrase inhibitor. Dolutegravir has been approved by the FDA to treat HIV-infection.
References:Penchala, S.D., et al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1027, 174 (2016); Rituraj et al.: Intl. J. Pharm. Sci. Res., 6, 4484 (2015)
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