Paclitaxel Impurity O

Chemical Name:Paclitaxel Impurity O
Synonyms:Paclitaxel EP Impurity O; (2aR,​4S,​4aS,​6R,​9S,​11S,​12S,​12aR,​12bS)​-​6,​12b-​bis(acetyloxy)​-​12-​(benzoyloxy)​-​2a,​3,​4,​4a,​5,​6,​9,​10,​11,​12,​12a,​12b-​dodecahydro-​4,​11-​dihydroxy-​4a,​8,​13,​13-​tetramethyl-​5-​oxo-​7,​11-​methano-​1H-​cyclodeca[3,​4]​benz[1,​2-​b]​oxet-​9-​yl (αR,​βS)​-α-​hydroxy-​β-​[[(2E)​-​1-​oxo-​3-​phenyl-​2-​propen-​1-​yl]​amino]​-​benzenepropanoic Acid
Impurity
Paclitaxel EP Impurity O
CAS Number:219783-77-4
Molecular Formula:C₄₉H₅₃NO₁₄
Molecular Weight:879.94
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Paclitaxel EP Impurity O is an impurity of Paclitaxel (P132500), an antineoplastic. Paclitaxel is used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi’s sarcoma.
References:Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),
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