Drug Delivery

Chemical Name:3-Hydroxymethylcholanthrene trans-9,10-DihydrodiolSynonyms:(9S-trans)-1,2,9,10-Tetrahydro-3-(hydroxymethyl)-benz[j]aceanthrylene-9,10-diolAlternate CAS #:177472-67-2 (S,S, trans); 177327-80-9 (R,R, trans)Molecular Formula:C₂₁H₁₈O₃Molecular Weight:318.37Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;Applications:3-Hydroxymethylcholanthrene trans-9,10-Dihydrodiol has been shown to be a metabolite of 3-Hydroxymethylcholanthrene (3-OHMC) when incubated with rat liver microsomes.References:Shou, M.; et al.: Drug Metab. Dispos, 24, 595 (1996)To ensure the stability of our products, the efficient express delivery service will […]

Chemical Name:2-Hydroxy-3-methylcholanthreneSynonyms:3-Methyl-2-cholanthrenol (7CI, 8CI); 1,2-Dihydro-3-methylbenz[j]aceanthrylen-2-ol; 3-Methylcholanthren-2-olCAS Number:3308-64-3Alternate CAS #:Parent compound: 56-49-5Molecular Formula:C₂₁H₁₆OMolecular Weight:284.35Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:2-Hydroxy-3-methylcholanthrene is a metabolite of 3-Methylcholanthrene, which is formed by liver microsomes in rats. The metabolism of the racemic mixture of 2-Hydroxy-3-methylcholanthrene was found to be enantiospecific; the rate of metabolism of the R isomer is faster than that of […]

Chemical Name:1-Hydroxy-3-methylcholanthreneSynonyms:1,2-Dihydro-3-methyl-benz[j]aceanthrylen-1-ol; 3-Methyl-1-cholanthrenol (7CI,8CI); 2-Dihydro-3-methylbenz[j]aceanthrylen-1-ol; 3-Methylcholanthren-1-olCAS Number:3342-98-1Alternate CAS #:Parent compound: 56-49-5Molecular Formula:C₂₁H₁₆OMolecular Weight:284.35Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:1-Hydroxy-3-methylcholanthrene is a major metabolite of 2-Methylcholanthrene and has been shown to exhibit carcinogenicity in rats at the site of injection, causing sarcomas in 42% of rats subjected to testing within 52 weeks of initial injection.References:Flesher, J.W.; et al.: Biochem. […]

Chemical Name:3-Hydroxymethylcholanthrene trans-11,12-DihydrodiolSynonyms:(11R-trans)-1,2,11,12-Tetrahydro-3-(hydroxymethyl)-benz[j]aceanthrylene-11,12-diol (9CI)Alternate CAS #:177327-81-0 (R,R, trans)Molecular Formula:C₂₁H₁₈O₃Molecular Weight:318.37Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;Applications:3-Hydroxymethylcholanthrene trans-11,12-Dihydrodiol has been shown to be a metabolite of 3-Hydroxymethylcholanthrene (3-OHMC) when incubated with rat liver microsomes.References:Shou, M.; et al.: Drug Metab. Dispos, 24, 595 (1996)To ensure the stability of our products, the efficient express delivery service will be used. […]

Chemical Name:3-Hydroxymethylcholanthrene trans-7,8-DihydrodiolSynonyms:(7R-trans)-1,2,7,8-Tetrahydro-3-(hydroxymethyl)-benz[j]aceanthrylene-7,8-diol (9CI)Alternate CAS #:177327-79-6 (R,R trans)Molecular Formula:C₂₁H₁₈O₃Molecular Weight:318.37Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;Applications:3-Hydroxymethylcholanthrene trans-7,8-Dihydrodiol has been shown to be a metabolite of 3-Hydroxymethylcholanthrene (3-OHMC) when incubated with rat liver microsomes.References:Shou, M.; et al.: Drug Metab. Dispos, 24, 595 (1996)To ensure the stability of our products, the efficient express delivery service will be used. […]

Chemical Name:2-(3-(4-Hydroxy-3,5-diiodophenoxy)-2,4-diiodobenzamido)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid, Amide-BridgedAlternate CAS #:Parent compound: 51-48-9Molecular Formula:C₂₈H₁₆I₇NO₇Molecular Weight:1366.76Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:2-(3-(4-Hydroxy-3,5-diiodophenoxy)-2,4-diiodobenzamido)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid, Amide-Bridged is a Levothyroxine impurity of Thyroxine (T425600), which is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Thyroxine is deiodinated in peripheral tissues to the active metabolite, liothyronine, which has been used to treat hyperlipidemia.References:Post, A., […]

Chemical Name:(2E,4E)-5-(4-Hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienalCAS Number:535950-02-8Molecular Formula:C₁₅H₂₂O₂Molecular Weight:234.33Category:Building Blocks; Miscellaneous;Applications:(2E,4E)-5-(4-Hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienal is an intermediate used in the synthesis of rac-all-trans 3-Hydroxy Retinal (80%) (H953285).To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products will be shipped in the box with layers of tapes to protect them against damage. […]

Chemical Name:(R)-1-(4-Hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl)-3-phenylpropan-1-oneMolecular Formula:C₂₀H₂₂O₄Molecular Weight:326.39Category:Building Blocks; Miscellaneous;Applications:(R)-1-(4-Hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl)-3-phenylpropan-1-one is a pharmaceutical intermediate.To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products will be shipped in the box with layers of tapes to protect them against damage. The extremely low temperature products will be wrapped with dried […]

Chemical Name:Hydroxy Saxagliptin-13C,D2 HydrochlorideSynonyms:(1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-carbonitrile-13C,D2 Hydrochloride; BMS 510849–13C,D2 Hydrochloride; 5-Hydroxy Saxagliptin-13C,D2 Hydrochloride; BMS 510849-13C,D2 Hydrochloride; M2 Saxagliptin Hydroxylated Metabolite-13C,D2 Hydrochloride;CAS Number:1572922-53-2Alternate CAS #:Unlabelled : 841302-24-7Free Base: 1573403-06-1Molecular Formula:C₁₇¹³CH₂₄D₂ClN₃O₃Molecular Weight:370.88Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:Isotope labelled Hydroxy-Saxagliptin. a metabolite of Saxagliptin (S143500).References:Patel, C. et al.: J. Clinic. Pharmacol., 50, 1211 (2010); Feng, J., et al.: J. Med. Chem., 50, […]

Chemical Name:all-trans-18-Hydroxy Retinoic AcidSynonyms:18-Hydroxy-all-trans-retinoic acid; 18-Hydroxyretinoic acid; Ro 12-4825;CAS Number:63531-93-1Molecular Formula:C₂₀H₂₈O₃Molecular Weight:316.43Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:all-trans-18-Hydroxy Retinoic Acid is hydroxylated metabolite of all-trans-Retinoic Acid (R250200) produce by cytochrome P450, CYP26C1.References:Taimi, M. et al.: J. Biol. Chem., 279, 77 (2004); Idres, N. et al.: J. Biol. Chem., 277, 31491 (2002); Hanni, R. et al.: Helv. Chim. Acta, […]