(S)-N-Despropyl Pramipexole Dihydroxysuccinate

Chemical Name:(S)-N-Despropyl Pramipexole Dihydroxysuccinate
Synonyms:(6S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine Dihydroxysuccinate; (S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole Dihydroxysuccinate; (S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine Dihydroxysuccinate; Pramipexole Related Compound A USP Dihydroxysuccinate; (S)-4,5,6,7-Tetrahydrobenzo[d]thiazole-2,6-diamine 2,3-dihydroxysuccinate
Alternate CAS #:free base: 106092-09-5
Molecular Formula:C₁₁H₁₇N₃O₆S
Molecular Weight:319.33
Category:Building Blocks; Miscellaneous;
Applications:(S)-N-Despropyl Pramipexole Maleate is an intermediate in the synthesis of (R)-Pramipexole Dihydrochloride (P700745), the opposite enantiomer of Pramipexole (P700755), a dopamine-D2-receptor agonist. Dexpramipexole is a low-molecular-weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics.
References:Mierau, J., et al.: J. Med. Chem., 30, 494 (1987); Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992); Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)
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