tert-Butyl 2-((4R,6R)-6-(chloromethyl)-2,2-dimethyl-1.3-dioxan-4-yl)acetate

Chemical Name:tert-Butyl 2-((4R,6R)-6-(chloromethyl)-2,2-dimethyl-1.3-dioxan-4-yl)acetate
Synonyms:(4R,6R)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
CAS Number:521974-01-6
Molecular Formula:C₁₃H₂₃ClO₄
Molecular Weight:278.77
Category:Building Blocks;
Applications:tert-Butyl 2-((4R,6R)-6-(chloromethyl)-2,2-dimethyl-1.3-dioxan-4-yl)acetate is an impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References:Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006);
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