CAS:1395950-84-1|(R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5)

Catalogue Number:C785001
Chemical Name:(R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5)
CAS Number:1395950-84-1
Alternate CAS #
877399-52-5
Molecular Formula:C₂₁H₁₇D₅Cl₂FN₅O
Appearance:Brown to Very Dark Brown Solid
Melting Point:197 – 199°C
Molecular Weight:455.37
Storage:4°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Chiral Molecules; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5) is the labelled version of Crizotinib (C785000), which is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Potent ALK inhibitor, potent c-MET inhibitor.
References:Zou, H.Y. et al.: Cancer Res., 67, 4408 (2007); Cui, J.J. et al.: J. Med. Chem., No pp given (2011); Sasaki, T. et al.: Cancer. Res. et al.: 70, 10038 (2010);
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