CAS:1422955-31-4|N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

Catalogue Number:C368260
Chemical Name:N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
CAS Number:1422955-31-4
Molecular Formula:C₁₂H₆ClFN₄O₃
Molecular Weight:308.65
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine is a HIF-2α inhibitor which inhibits HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain. It may be used in therapeutic treatment of HIF-2-driven tumors such as renal cell carcinomas.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Rogers, J., et al.: J. Med. Chem., 56, 1739 (2013); Scheuermann, T., et al.: Nat. Chem. Biol., 9, 271 (2013)
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