CAS:163451-81-8|A 77-1726

Catalogue Number:A771726
Chemical Name:A 77-1726
Synonyms:N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M; Teriflunomide; Leflunomide EP Impurity B; Aubagio; A1726; (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Femorix; HMR 1726; SU 20
Impurity:Leflunomide EP Impurity B
CAS Number:163451-81-8
Alternate CAS #
108605-62-5 (Unspecified Stereochemistry)p
Molecular Formula:C₁₂H₉F₃N₂O₂
Appearance:White to Off-White Solid
Melting Point:229-232°C
Molecular Weight:270.21
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Sparingly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).
References:Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)
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