CAS:1797989-42-4|CHIR-99021 Hydrochloride

Catalogue Number:C292150
Chemical Name:CHIR-99021 Hydrochloride
Synonyms:6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride; CHIR99021
CAS Number:1797989-42-4
Alternate CAS #
Free Base: 252917-06-9
Molecular Formula:C₂₂H₁₉Cl₃N₈
Appearance:Off-White to Pale Beige Solid
Melting Point:>238°C (dec.)
Molecular Weight:501.8
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. GSK-3a/b inhibitor
References:Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);
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